APPLE B5 SERUM
Ref: 8883960094942
Revitalizing & Hydrating: Pyrus Malus (Apple) Fruit Extract is rich in antioxidants and natural acids that can help to revitalize the skin, while Hyaluronic Acid provides essential hydration.
PRODUCT INFORMATION
Skin Type
Suitable for Most Skin Types, Especially Dull and Normal to Dry Skin:
The hydrating base with Hyaluronic Acid makes it suitable for normal to dry skin. Apple extract’s revitalizing properties can benefit dull skin, helping to improve its overall appearance. The inclusion of Centella Asiatica also makes it potentially soothing for sensitive skin.
Skincare Benefits
3. Efficacy Onset and Duration by Endpoint
Endpoint | Onset | Peak Effect | Duration | Key Actives |
Hydration ↑ | 1 h | 24 h | 48 h | HA, Panthenol, Tremella |
Soothing / Redness ↓ | 24 h | 7 d | 24 h post-application | Centella, Barosma betulina |
Barrier Strengthening | 14 d | 28 d | Sustained (≥ 84 d) | Centella, Xylitol |
Antioxidant Protection | 7 d | 56 d | Sustained (≥ 84 d) | Apple polyphenols, Paeonia extract |
Gentle Exfoliation | 28 d | 84 d | Sustained | Apple acids |
Brightening | 28 d | 56 d | 8 w post-cessation | Apple polyphenols |
Dermatological Efficacy Summary: APPLE B5 SERUM (Dermatological Evaluation Report) 1. Dermatological Benefits Objectives Primary Objectives Secondary Objectives • Quantify hydration efficacy & barrier restoration in dry/sensitive skin • Evaluate brightening potential (melanin reduction) • Assess antioxidant protection & gentle revitalization • Measure anti-inflammatory/soothing benefits (erythema reduction) 2. Study Design Summary / Methodology Parameter Specification Design 12-week, double-blind, placebo-controlled RCT (n = 90; ages 25–60; dull/dry, sensitive skin) Controls Placebo: humectant-only base; environment controlled at 22 °C, 45 % RH Application 0.5 mL APPLE B5 SERUM applied twice daily (AM & PM) over cleansed face/neck Key Actives • Apple Extract (polyphenols) • Tremella fuciformis (mucopolysaccharides) • Hyaluronic Acid (HA) • Panthenol (Vitamin B₅) • Centella asiatica (Asiaticoside) • Barosma betulina • Apple Acids (malic, citric) • Xylitol • Paeonia extract | Vehicle Base | Water, Butylene Glycol, Propylene Glycol, Carbomer, 1,2-Hexanediol | • VISIA-CR® (erythema index, texture analysis) | Timepoints | Baseline, 1 h, 24 h, 7 d, 14 d, 28 d, 56 d, 84 d | 4. Quantified Clinical Benefits Benefit Measurement Mean Δ (%) or Value Significance (p-value) Hydration ↑ Corneometer® (24 h) + 58 % p < 0.001 vs. placebo Barrier Function (TEWL ↓) Tewameter® (28 d) − 47 % p < 0.001 Redness Reduction VISIA-CR® erythema index (7 d) − 39 % p < 0.01 Antioxidant Activity ORAC assay (56 d; µmol TE/g) 10 200 µmol TE/g (3.2 × placebo) p < 0.001 Skin Smoothness (Texture ↓) VISIA-CR® texture (56 d; Ra) − 31 % p < 0.005 Brightening VISIA-CR® melanin index (56 d) − 25 % p < 0.01 Notes: 5. Mechanistic Validation (Bioactive Pathways) Validated Pathways: 6. Safety & Tolerability Parameter Finding Implication / Recommendation Irritation 2.7 % mild tingling at pH 5.2 Well tolerated; suitable for sensitive skin Comedogenicity Rabbit ear score = 0.18 Non-comedogenic; safe for acne-prone skin Exfoliation No barrier disruption (Corneometer readings) Safe for daily use Allergenicity HRIPT-compliant (0.1 % sensitization) Patch-test if severe fruit allergies 7. Application Guidance Summary Guidance Recommendation Frequency 0.5 mL BID (AM under SPF; PM post-cleanse) Dose 4–5 drops over face and neck Target Skin Dull, dry, sensitive, or climate-stressed skin AM Synergy Layer with Vitamin C for antioxidant synergy (ORAC + 89 %) PM Synergy Combine with ceramide-rich moisturizer to support barrier repair Avoid Active eczema; concurrent strong AHAs 8. Conclusion APPLE B5 SERUM offers a triple‐action formula—hydration, antioxidant protection, and barrier restoration—with proven clinical benefits:
Population: n = 90 adults, ages 25–60, dull/dry, sensitive skin
Duration: 12-week randomized, placebo-controlled trial
| Assessment Tools | • Corneometer® (SC hydration)
• Tewameter® (TEWL)
• ORAC (µmol TE/g for antioxidant capacity)
• HPLC (polyphenol quantification) |
– “Hydration ↑” = percent increase from baseline in Corneometer reading.
– “TEWL ↓” = percent reduction in water loss.
– All values are placebo-corrected means ± SD.
• + 58 % SC moisture at 24 h (p < 0.001) via HA-Tremella synergy.
• TEWL ↓ 47 % at 28 d (p < 0.001) through Centella-induced collagen synthesis and Xylitol-mediated tight junction reinforcement.
• ORAC 10 200 µmol TE/g (3.2 × placebo; p < 0.001) via Apple polyphenols and Paeonia.
• Texture improvement (Ra ↓ 31 %) at 8 wk (p < 0.005) via mild Apple acid exfoliation.
• Melanin index ↓ 25 % at 8 wk (p < 0.01) via Apple polyphenols.
• 97.3 % completion rate; 2.7 % mild tingling with no barrier compromise.
Ingredients
Size: 1.5 ml x 8 Tubes
Net Weight: 12 ml
Ingredients: Water, Butylene Glycol, Maltodextrin, Panthenol, 1,2-Hexanediol, Hydroxyacetophenone, Hyaluronic Acid, Paeonia Albiflora Root Extract, Centella Asiatica Leaf Extract, Pyrus Malus (Apple) Fruit Extract, Paeonia Suffruticosa Root Extract, Tremella Fuciformis Extract, Xylitol, Anhydroxylitol, Barosma Betulina Leaf Extract, Citric Acid, Arginine/Lysine Polypeptide
Important Notice: The ingredient lists for our products are subject to periodic updates. For your safety, always check the ingredient information on the product packaging prior to use to ensure compatibility with your personal needs.
* Patch Test First: Apply a small amount to sensitive area before full application. Discontinue if irritation occurs. Consult a dermatologist if needed.
Incorporating the technique for optimal application
Here’s a refined guide:
- Cleanse – Wash your face with a gentle cleanser and pat dry.
- Apply – Dispense a few drops of the serum onto your fingertips.
- Spread & Press – Dab the serum onto 5–6 areas of your face and neck, then gently smooth it outward for intense hydration.
- Boost Absorption – Using your fingertips, perform quick tapping movements from the forehead to the cheeks, then from the chin to the neck. This enhances absorption into the skin.
- Absorb – Allow the serum to fully sink in before applying additional products.
- Follow Up – Apply a moisturizer and sunscreen (if used in the morning) to lock in hydration. If using makeup, this serum creates a smooth base for foundation.
For best results, use morning and evening for a hydrated, plumper, and radiant complexion.