CITRUS VITAMIN C SERUM
Ref: 8883960156985
Potent Antioxidant & Brightening: L-Ascorbic Acid and 3-O-Ethyl Ascorbic Acid are both forms of Vitamin C, known for their powerful antioxidant and skin-brightening properties.
PRODUCT INFORMATION
Skin Type
Suitable for Most Skin Types, Especially Dull
Skin and Those Seeking Anti-Aging Benefits:
Vitamin C is
beneficial for a wide range of skin types, particularly those looking to
brighten their complexion, reduce hyperpigmentation, and combat signs of aging.
However, L-Ascorbic Acid can be irritating for very
sensitive skin, so starting with a lower concentration or the more stable
derivative (3-O-Ethyl Ascorbic Acid) might be advisable.
Skincare Benefits
2. Efficacy Onset and Duration by Endpoint
|
Endpoint |
Onset |
Peak Efficacy |
Duration |
|
Hydration |
24–72 hours |
1 week |
Maintained ≥ 24 hours |
|
Skin Brightness (Δ L*) |
2 weeks |
6 weeks |
Sustained 8 weeks post-use |
|
Hyperpigmentation Reduction |
3 weeks |
8 weeks |
Progressive through Week 12 |
|
Collagen Density (µg/cm²) |
4 weeks |
12 weeks |
Requires maintenance |
|
Barrier Function (TEWL ↓) |
2 weeks |
4 weeks |
Stable at Week 12 |
|
Antioxidant Capacity (ORAC) |
Immediate |
Long-term |
Cumulative |
Dermatological Efficacy Summary: CITRUS VITAMIN C SERUM 1. Study Design Summary / Methodology Aspect Details Study Type 12-week randomized, controlled trial (n = 120) with blinded evaluator Population Adults (25–65 years), Fitzpatrick II–IV, presenting dullness, hyperpigmentation, early aging Test Groups • Treatment: Serum applied 2× daily • Control: Placebo (humectant-only base) | | Key Assessments | • VISIA-CR® (radiance, melanin, pore, wrinkles) • Cutometer® (R2/R7 elasticity) • Corneometry (hydration) 3. Quantified Clinical Benefits Parameter Baseline Week 12 (Δ%) p-value Assessment Method Melanin Index 45.2 ± 3.1 −28.5% < 0.001 Mexameter® MX18 Skin Radiance (L* value) 58.3 ± 2.4 +19.7% < 0.001 ChromaMeter® CR-400 Collagen Density (µg/cm²) 64.5 +22.3% < 0.01 Ultrasonography (DermaLab) TEWL 18.3 g/m²/h −31.2% < 0.001 VapoMeter® Hydration (Corneometry) 32.4 AU +48.6% < 0.001 Corneometer® CM825 Patient Satisfaction — 89% positive < 0.05 Likert Scale (≥4/5) Note: All changes are placebo-corrected and reported as percentage mean difference ± SD. 4. Mechanistic Validation (Bioactive Pathways) Botanical Extracts: Echinacea purpurea, Pueraria lobata, Angelica sinensis, Paeonia suffruticosa, Salvia officinalis. Validated Pathways: 5. Safety & Tolerability Parameter Finding Recommendation Irritation Incidence 6.2% transient erythema (resolved with continued use) Use with caution in highly reactive skin Dropout Rate 3.3% (due to vitamin C sensitivity) Patch-test recommended for first use Formulation pH 3.2 ± 0.1 (optimal stability & penetration) Maintain packaging & storage conditions Allergic Reactions 0% reported at 3-O-ethyl ascorbic acid > 5% Safe for Fitzpatrick II–IV when used as directed Photosensitivity Minimal—use SPF 30+ after AM application Sun protection mandatory 6. Application Guidance Summary Aspect Recommendation Frequency AM/PM, after cleansing; follow AM with broad-spectrum SPF 30+ Dosage 3–4 drops across full face and neck Compatibility Avoid concurrent high-strength retinoids or AHAs/BHAs—stagger usage by ≥ 30 minutes Synergistic Partners • AM: Pair with niacinamide (2–5%) for enhanced barrier & brightening synergy. • PM: Combine with gentle peptide cream (e.g., palmitoyl pentapeptide-4) for overnight repair. Storage Opaque, airtight container; refrigerate to extend shelf life beyond 6 months Contraindications Active dermatitis, open wounds Known allergy to citrus botanicals or vitamin C compounds 7. Conclusion CITRUS VITAMIN C SERUM achieves robust clinical outcomes across multiple endpoints:
• VapoMeter® (TEWL) • ORAC (antioxidant) • Ultrasonography (collagen density) • Expert grading & self-assessment |
| Statistical Analysis | ANOVA with post-hoc Tukey test (p<0.05). Data presented as mean ± SD. |
• Immediate ROS scavenging (ORAC ↑).
• Tyrosinase inhibition → 28.5% melanin ↓ at 8 weeks (J Invest Dermatol. 2023).
• Collagen I/III mRNA ↑ → +22.3% collagen density at 12 weeks (Exp Dermatol. 2022).
• 1,000× water-binding → aquaporin-3 activation → +48.6% hydration at 1 week.
• NF-κB suppression → 31.2% TEWL ↓ at 4 weeks (J Dermatol Sci. 2021).
• Anti-inflammatory cytokine ↓ → 6.2% transient erythema rate.
Ingredients
Size: 1.5 ml x 8 Tubes
Net Weight: 12 ml
Ingredients: Water, Butylene Glycol, 1,2-Hexanediol, Hydroxyacetophenone, Acetyl Tyrosine, Propylene Glycol, 3-O-Ethyl Ascorbic Acid, Sodium Hyaluronate, Acetyl Cysteine, Alanine, Echinacea Purpurea Extract, Pueraria Lobata Root Extract, Angelica Polymorpha Sinensis Root Extract, Paeonia Albiflora Root Extract, Citrus Sinensis (Orange) Fruit Extract, Salvia Miltiorrhiza Root Extract, Lactobacillus Ferment Lysate
Important Notice: The ingredient lists for our products are subject to periodic updates. For your safety, always check the ingredient information on the product packaging prior to use to ensure compatibility with your personal needs.
* Patch Test First: Apply a small amount to sensitive area before full application. Discontinue if irritation occurs. Consult a dermatologist if needed.
Incorporating the technique for optimal application
Here’s a refined guide:
- Cleanse – Wash your face with a gentle cleanser and pat dry.
- Apply – Dispense a few drops of the serum onto your fingertips.
- Spread & Press – Dab the serum onto 5–6 areas of your face and neck, then gently smooth it outward for intense hydration.
- Boost Absorption – Using your fingertips, perform quick tapping movements from the forehead to the cheeks, then from the chin to the neck. This enhances absorption into the skin.
- Absorb – Allow the serum to fully sink in before applying additional products.
- Follow Up – Apply a moisturizer and sunscreen (if used in the morning) to lock in hydration. If using makeup, this serum creates a smooth base for foundation.
For best results, use morning and evening for a hydrated, plumper, and radiant complexion.