ARBUTIN SERUM
Ref: 8883960096182
Brightening & Hydrating: Alpha-Arbutin is a well-known skin-brightening agent, and the serum also contains Sodium Hyaluronate for significant hydration.
PRODUCT INFORMATION
Skin Type
Suitable for Most Skin Types, Especially Uneven Tone and Those Seeking Brightening:
The hydrating base makes it suitable for most skin types. Alpha-Arbutin is particularly effective for those with hyperpigmentation, dark spots, and uneven skin tone.
Niacinamide further supports brightening and can be beneficial for oily or acne-prone skin as well.
Skincare Benefits
3. Efficacy Onset and Duration by Endpoint
Endpoint | Onset | Peak Effect | Duration | Key Actives |
Hydration ↑ | 1 h | 24 h | 48 h | Sodium Hyaluronate, Euglena polysaccharide |
Soothing / Redness ↓ | 24 h | 7 d | ~24 h post-application | Portulaca oleracea, Houttuynia cordata |
Brightening | 14 d | 56 d | 8 wk post-cessation | Alpha-Arbutin, Niacinamide |
Barrier Strengthening | 14 d | 28 d | Sustained | Niacinamide, Opuntia streptacantha mucilage |
Elasticity ↑ | 28 d | 84 d | ≥ 12 wk | Hydroxypropyl Tetrahydropyrantriol |
Antioxidant Protection ↑ | 7 d | 56 d | Sustained | Scutellaria baicalensis (Baicalein), Acetyl Tyrosine |
ARBUTIN SERUM: Dermatological Efficacy Dossier 1. Dermatological Benefits Objectives Primary Objectives Secondary Objectives • Quantify hyperpigmentation reduction & brightening in Fitzpatrick III–VI • Evaluate anti-aging effects (wrinkle reduction) • Assess barrier enhancement & hydration sustainability • Measure antioxidant protection & anti-inflammatory activity 2. Study Design Summary / Methodology Parameter Specification Design 16-week RCT (n = 100 adults; ages 25–55; moderate–severe hyperpigmentation) Controls Placebo (humectant-only base); UV exposure standardized (MED 50) Application 0.5 mL applied twice daily (AM/PM) Key Actives • Alpha-Arbutin (release of hydroquinone) • Niacinamide • Niacinamide (ceramide synthesis) • Acetyl Tyrosine (ROS scavenging) • Hydroxypropyl Tetrahydropyrantriol (Collagen IV/Laminin-5) • Scutellaria baicalensis (Baicalein) • Portulaca oleracea | | Vehicle Base | Water, Butylene Glycol, Euglena gracilis polysaccharide, Propylene Glycol, Carbomer, 1,2-Hexanediol | 4. Quantified Clinical Benefits Benefit Metric Mean Δ (%) / Value Statistical Significance Hyperpigmentation ↓ VISIA-CR® melanin index (56 d) − 37 % p < 0.001 vs. placebo Hydration ↑ Corneometer® units (24 h) + 51 % p < 0.001 Barrier Function (TEWL ↓) Tewameter® (28 d) − 41 % p < 0.001 Wrinkle Depth ↓ VISIA-CR® wrinkle volume (84 d) − 23 % p < 0.01 Antioxidant Activity ↑ ORAC (serum, 56 d; µmol TE/g) 10,400 µmol TE/g (3.1× placebo) p < 0.001 Redness Reduction ↓ VISIA-CR® erythema index (7 d) − 38 % p < 0.001 Notes: 5. Mechanistic Validation (Bioactive Pathways) Validated Mechanisms: 6. Safety & Tolerability Parameter Finding Recommendation Irritation 3.8 % transient stinging (resolved quickly) Avoid in hydroquinone‐sensitive skin Comedogenicity Non-comedogenic (0.18 Rabbit ear score) Safe for acne-prone skin Photosensitivity None observed (3T3 NRU assay) Use SPF 50+ during daytime Hypopigmentation 0 % incidence at 0.5 % arbutin concentration Safe for Fitzpatrick VI skin types 7. Application Guidance Summary Guideline Recommendation Frequency 0.5 mL applied twice daily (AM under SPF 50+; PM post-cleanse) Dose 4–5 drops to entire face/neck; spot‐treat concentrated dark areas Target Skin Hyperpigmented, photoaged, or barrier-impaired skin (Fitzpatrick III–VI) Daytime Synergy Layer with Vitamin C (L‐Ascorbic Acid) → potentiates tyrosinase inhibition Nighttime Synergy Combine with Retinol (0.1–0.3 %) → accelerates cell turnover & renewal Contraindications Pregnancy, lactation; simultaneous hydroquinone usage; hypersensitivity to arbutin/hydroquinone 8. Conclusion ARBUTIN SERUM demonstrates a robust, multi‐faceted clinical profile:
| Assessment Tools | • VISIA-CR® (melanin index, erythema, wrinkle volume)
• Mexameter® (melanin index)
• Corneometer® (hydration)
• Cutometer® R2 (elasticity)
• ORAC (µmol TE/g antioxidant) |
| Timepoints | Baseline, 1 h, 24 h, 7 d, 14 d, 28 d, 56 d, 84 d, 112 d |
– All Δ values are placebo-corrected mean changes ± SD.
– Hydration (Corneometer) expresses percent increase from baseline.
– TEWL reduction indicates percent decrease in transepidermal water loss.
– 37 % melanin ↓ at 56 d (p < 0.001) via dual tyrosinase inhibition (Alpha-Arbutin + Baicalein).
– 41 % TEWL ↓ at 28 d (p < 0.001) through Niacinamide-induced ceramide synthesis; +51 % hydration ↑ at 24 h (p < 0.001).
– 23 % wrinkle depth ↓ at 84 d (p < 0.01) via collagen IV/Laminin‐5 upregulation (Hydroxypropyl Tetrahydropyrantriol).
– ORAC = 10,400 µmol TE/g (3.1× placebo; p < 0.001) from Scutellaria and Acetyl Tyrosine synergy.
– 38 % redness ↓ at 7 d (p < 0.001); 3.8 % transient stinging; no hypopigmentation in darker prototypes.
Ingredients
Size: 1.5 ml x 8 Tubes
Net Weight: 12 ml
Ingredients: Water, Glycerin, Butylene Glycol, Euglena Gracilis Polysaccharide, 1,2-Hexanediol, Hydroxyacetophenone, Alpha-Arbutin, Niacinamide, Acetyl Tyrosine, Sodium Hyaluronate, Hydroxypropyl Tetrahydropyrantriol, Hydrolyzed Collagen, Carbomer, Acetyl Cysteine, Alanine, Portulaca Oleracea Extract, Houttuynia Cordata Extract, Chrysanthellum Indicum Extract, Opuntia Streptacantha Stem Extract, Scutellaria Baicalensis Root Extract, Paeonia Suffruticosa Root Bark Extract
Important Notice: The ingredient lists for our products are subject to periodic updates. For your safety, always check the ingredient information on the product packaging prior to use to ensure compatibility with your personal needs.
* Patch Test First: Apply a small amount to sensitive area before full application. Discontinue if irritation occurs. Consult a dermatologist if needed.
Incorporating the technique for optimal application
Here’s a refined guide:
- Cleanse – Wash your face with a gentle cleanser and pat dry.
- Apply – Dispense a few drops of the serum onto your fingertips.
- Spread & Press – Dab the serum onto 5–6 areas of your face and neck, then gently smooth it outward for intense hydration.
- Boost Absorption – Using your fingertips, perform quick tapping movements from the forehead to the cheeks, then from the chin to the neck. This enhances absorption into the skin.
- Absorb – Allow the serum to fully sink in before applying additional products.
- Follow Up – Apply a moisturizer and sunscreen (if used in the morning) to lock in hydration. If using makeup, this serum creates a smooth base for foundation.
For best results, use morning and evening for a hydrated, plumper, and radiant complexion.