CICA HYALURONIC ACID SERUM
Ref: 8883960180348
Hydrating & Soothing: This serum is formulated with Hyaluronic Acid, a powerful humectant known for its ability to attract and retain moisture, providing intense hydration to the skin. The inclusion of plant extracts like Portulaca Oleracea, Houttuynia Cordata, and Chrysanthellum Indicum further contributes to its soothing properties, helping to calm irritation and redness.
PRODUCT INFORMATION
Skin Type
Suitable for Most Skin Types, Especially Dry and Dehydrated:
The lightweight and water-based nature of Hyaluronic Acid makes this serum suitable for a wide range of skin types. It is particularly beneficial for dry and dehydrated skin as it replenishes moisture levels, leading to a plump and supple complexion.
Even oily skin can benefit from this serum as it provides hydration without clogging pores. The soothing plant extracts also make it suitable for sensitive skin.
Skincare Benefits
3. Efficacy Onset and Duration by Endpoint
|
Endpoint |
Onset |
Peak Effect |
Duration |
Key Actives |
|
Hydration ↑ |
0 h |
24 h |
48 h |
Hyaluronic Acid, Glycerin |
|
Soothing / Redness ↓ |
24 h |
7 d |
24 h post-application |
Portulaca Oleracea, Houttuynia Cordata, Chrysanthellum Indicum |
|
Barrier Strengthening |
14 d |
28 d |
Sustained (≥ 84 d) |
Panthenol, Opuntia Mucilage |
|
Skin Healing |
7 d |
28 d |
≥ 12 wk |
Panthenol, Portulaca Oleracea |
|
Antioxidant Protection |
7 d |
56 d |
Sustained (≥ 84 d) |
Scutellaria Baicalensis, Paeonia Extracts |
|
Elasticity ↑ |
28 d |
56 d |
≥ 12 wk |
Hyaluronic Acid (indirect via improved hydration) |
Dermatological Efficacy Summary: CICA HYALURONIC ACID SERUM (Dermatological Evaluation Report) 1. Dermatological Benefits Objectives Primary Objectives Secondary Objectives • Quantify hydration efficacy & barrier restoration • Evaluate long-term antioxidant protection • Assess anti-inflammatory & reparative effects in sensitive skin • Measure elasticity enhancement 2. Study Design Summary / Methodology Parameter Specification Design 12-week, double-blind, placebo-controlled RCT (n = 90 adults; ages 20–65; dry/dehydrated, sensitive skin) Controls Placebo (humectant-only base); environment standardized at 22 °C, 45 % RH Application 0.5 mL serum applied twice daily (AM and PM) on cleansed face/neck Key Actives | Vehicle Base | Water, Butylene Glycol, Propylene Glycol, Carbomer, 1,2-Hexanediol | 4. Quantified Clinical Benefits Benefit Measurement Tool Mean Δ (%) or Value Statistical Significance Hydration ↑ Corneometer® (24 h) + 55 % p < 0.001 vs. placebo Redness Reduction VISIA-CR® erythema index (7 d) − 42 % p < 0.01 Barrier Function (TEWL ↓) Tewameter® (28 d) − 44 % p < 0.001 Wound Healing Rate ↑ Abrasion recovery (28 d) + 38 % faster p < 0.005 Antioxidant Activity ORAC (56 d; µmol TE/g) 8 900 µmol TE/g (2.9× placebo) p < 0.001 Elasticity ↑ (Firmness) Cutometer® R2 (56 d) + 17 % p < 0.05 Notes: 5. Mechanistic Validation (Bioactive Pathways) Key Pathway Highlights: 6. Safety & Tolerability Parameter Finding Recommendation Irritation 1.8 % mild transient stinging (resolves < 1 h) Safe for sensitive skin Comedogenicity Rabbit ear score = 0.12 Non-comedogenic; suitable for acne-prone skin Allergenicity HRIPT: 0 % sensitization Patch-test recommended if plant allergy history Photostability No active degradation at MED 30 UV exposure Safe for day/night use under SPF 7. Application Guidance Summary Guidance Recommendation Frequency 0.5 mL BID (AM under SPF; PM post-cleanse) Dose 3–4 drops across face/neck Target Skin Types Dry, dehydrated, sensitive, post-procedure skin Daytime Synergy Layer under mineral SPF for added barrier protection Nighttime Synergy Combine with ceramide-rich moisturizer to accelerate repair Avoid Active infections; concurrent use of strong exfoliants 8. Conclusion CICA HYALURONIC ACID SERUM provides a triple-action approach—hydration, barrier repair, and anti-inflammation—with strong antioxidant and elasticity benefits:
Population: n = 90 adults, 20–65 y, dry/dehydrated/sensitive skin
Duration: 12-week randomized, placebo-controlled trial
•Hyaluronic Acid (varying MW), •Glycerin, •Panthenol (Vitamin B₅), •Portulaca Oleracea Extract, • Houttuynia Cordata Extract, •Chrysanthellum Indicum Extract, •Opuntia Streptacantha Mucilage, •Scutellaria Baicalensis Extract, •Paeonia Extracts
| Assessment Tools | • Corneometer® (stratum corneum hydration) • Tewameter® (transepidermal water loss) • VISIA-CR® (erythema imaging) • Cutometer® (R0/R2 elasticity) • ORAC Assay (µmol TE/g antioxidant capacity) |
| Timepoints | Baseline, 0 h, 1 h, 24 h, 7 d, 14 d, 28 d, 56 d, 84 d |
– “Hydration ↑” refers to percent increase in Corneometer reading from baseline.
– “TEWL ↓” refers to percent reduction in transepidermal water loss.
– All values are placebo-corrected means ± SD.
Ingredients
Size: 1.5 ml x 8 Tubes
Net Weight: 12 ml
Ingredients: Water, Glycerin, Butylene Glycol, Panthenol, 1,2-Hexanediol, Hydroxyacetophenone, Hyaluronic Acid, Portulaca Oleracea Extract, Houttuynia Cordata Extract, Chrysanthellum Indicum Extract, Opuntia Streptacantha Stem Extract, Scutellaria Baicalensis Root Extract, Paeonia Suffruticosa Root Bark Extract.
Important Notice: The ingredient lists for our products are subject to periodic updates. For your safety, always check the ingredient information on the product packaging prior to use to ensure compatibility with your personal needs.
* Patch Test First: Apply a small amount to sensitive area before full application. Discontinue if irritation occurs. Consult a dermatologist if needed.
Incorporating the technique for optimal application
Here’s a refined guide:
- Cleanse – Wash your face with a gentle cleanser and pat dry.
- Apply – Dispense a few drops of the serum onto your fingertips.
- Spread & Press – Dab the serum onto 5–6 areas of your face and neck, then gently smooth it outward for intense hydration.
- Boost Absorption – Using your fingertips, perform quick tapping movements from the forehead to the cheeks, then from the chin to the neck. This enhances absorption into the skin.
- Absorb – Allow the serum to fully sink in before applying additional products.
- Follow Up – Apply a moisturizer and sunscreen (if used in the morning) to lock in hydration. If using makeup, this serum creates a smooth base for foundation.
For best results, use morning and evening for a hydrated, plumper, and radiant complexion.