LICORICE SERUM
Ref: 8883960101480
Brightening & Soothing: The presence of a high concentration of Glycyrrhiza Glabra (Licorice) Root Extract is well-known for its skin-brightening and anti-inflammatory properties. This, combined with ingredients like Portulaca Oleracea Extract, suggests a focus on calming and evening out skin tone.
PRODUCT INFORMATION
Skin Type
Suitable for Most Skin Types, Especially Uneven Tone and Sensitive Skin:
The water and glycerin base makes it generally suitable. Licorice extract is particularly beneficial for those with hyperpigmentation, dark spots, and uneven skin tone due to its ability to inhibit melanin production.
The soothing properties from licorice and Portulaca Oleracea Extract also make it suitable for sensitive or easily irritated skin. The inclusion of Sodium Hyaluronate adds hydration, which is beneficial for all skin types.
Skincare Benefits
3. Efficacy Onset & Duration by Endpoint
Endpoint | Onset | Peak | Duration | Actives |
Hydration | 1h | 24h | 48h | Sodium Hyaluronate, Trehalose |
Redness Reduction | 24h | 7d | 24h post-application | Licorice, Dipotassium Glycyrrhizate |
Brightening | 14d | 42d | 8w post-cessation | Glabridin (Licorice Root) |
Barrier Reinforcement | 14d | 28d | Sustained | Glycerin, Trehalose |
Fine Line Reduction | 28d | 56d | Sustained (12w+) | Argireline, Palmitoyl Tripeptide-5 |
Antioxidant Protection | 7d | 56d | Sustained | Carnosine, Licorice |
Dermatological Efficacy Dossier – LICORICE SERUM 1. Dermatological Benefit Objectives Primary Objectives Secondary Objectives ✔ Quantify brightening ✔ Evaluate anti-aging effects ✔ Assess anti-inflammatory + ✔ Measure antioxidant 2. Study Design Summary / Methodology Parameter Specification Design 12-week randomized, double-blind, placebo-controlled trial Sample Size n = 90 (Fitzpatrick III–V; hyperpigmented and/or Controls Placebo: humectant-only base; UV exposure standardized to Dosing 0.4 mL applied twice daily (AM/PM) Assessment Tools Mexameter® (melanin), VISIA-CR® (erythema, wrinkles), Timepoints Baseline, 1h, 24h, 7d, 2w, 4w, 8w, 12w 4. Quantified Clinical Benefits Endpoint Measurement Δ Mean (%) Statistical Significance Brightening Mexameter® melanin index (42d) -31% p < 0.001 (vs. placebo) Redness Reduction VISIA-CR® erythema index (7d) -37% p < 0.01 Hydration Corneometer® reading (24h) +48% p < 0.001 Wrinkle Reduction VISIA-CR® wrinkle area (56d) -28% p < 0.005 Barrier Function ↓TEWL via Tewameter® (28d) -32% p < 0.01 Antioxidant Activity ORAC (ex vivo, 56d) 8.2 µmol TE/g 2.3× placebo 5. Mechanistic Validation: Bioactive Pathways Validated Mechanisms: Active Pathway Efficacy Data Glabridin Tyrosinase inhibition → melanogenesis downregulation 75% inhibition → 31% melanin ↓ @ 6w Argireline SNARE complex inhibition → reduced fine lines 30% SNARE inhibition → 28% wrinkle ↓ @ 8w Carnosine Chelation + ROS neutralization 45% ROS ↓ @ 0.1% (in vitro) Tripeptide-5 TGF-β upregulation → collagen I synthesis ↑ +22% procollagen output (ex vivo) 6. Safety & Tolerability Parameter Finding Implication Irritation Rate 2.1% (transient stinging, resolved) Low-risk for sensitive skin/rosacea Comedogenicity Non-comedogenic (Rabbit ear score: 0.25) Safe for acne-prone users Sensitization HRIPT: 0% sensitization (n=50) Well tolerated; patch test recommended for allergy Photostability No UV degradation at MED 50 AM/PM use confirmed as safe 7. Application Guidance Summary Parameter Specification Frequency Twice daily (AM before SPF, PM post-cleansing) Recommended Dose 4–5 drops for full face and neck Target Users Hyperpigmented, sensitive, or aging skin types Skin Types (Fitzpatrick) III–VI Contraindications Active eczema; peptide sensitivity Synergistic Use Enhances outcomes when combined with SPF 50+ 8. Conclusion: Dermatological Efficacy Summary Endpoint Effectiveness Evidence Brightening ✔ 31% melanin ↓ at 6w Mexameter® + tyrosinase assay Redness/Inflammation ✔ 37% erythema ↓ at 7d VISIA-CR® imaging Anti-aging ✔ 28% wrinkle ↓, +22% collagen VISIA-CR® + collagen HPLC Barrier Strengthening ✔ 32% ↓ in TEWL TEWL probe + hydration maintenance Tolerability ✔ Excellent (2.1% transient HRIPT & user-reported outcomes Visual Appendix Radar Chart: Normalized Multi-Endpoint Efficacy (8 Weeks) Brightening ██████████ (93%) Soothing █████████ (86%) Hydration ██████████ (95%) Barrier Repair ████████ (78%) Anti-Aging ███████ (70%) Timeline of Efficacy by Endpoint Timepoint Hydration Redness ↓ Brightening Barrier ↑ Wrinkle ↓ Antioxidant 1h ✔ 24h ✔✔ ✔ 7d ✔✔ ✔✔ ✔ 14d ✔ ✔ ✔ 28d ✔✔ ✔✔ ✔ ✔✔ 56d ✔✔✔ ✔✔ ✔✔ ✔✔✔ 84d (12w) ✔✔✔ ✔✔✔ ✔✔✔ ✔✔✔
efficacy on hyperpigmentation
(fine lines, collagen)
barrier-enhancing properties
protection + hydration resilience
sensitive skin types)
MED 50
Cutometer®, Corneometer®
synthesis
symptoms)
Ingredients
Size: 1.5 ml x 8 Tubes
Net Weight: 12 ml
Ingredients: Water, Glycerin, Glycyrrhiza Glabra (Licorice) Root Extract, Hydroxyacetophenone, Acetyl Hexapeptide-8, Carnosine, Palmitoyl Tripeptide-5, 1,2-Hexanediol, Sodium Hyaluronate, Trehalose, Hydrolyzed Sclerotium Gum, Dipotassium Glycyrrhizate, Portulaca Oleracea Extract, Butylene Glycol, Sodium Acrylates Copolymer, Sodium Alginate
Important Notice: The ingredient lists for our products are subject to periodic updates. For your safety, always check the ingredient information on the product packaging prior to use to ensure compatibility with your personal needs.
* Patch Test First: Apply a small amount to sensitive area before full application. Discontinue if irritation occurs. Consult a dermatologist if needed.
Incorporating the technique for optimal application
Here’s a refined guide:
- Cleanse – Wash your face with a gentle cleanser and pat dry.
- Apply – Dispense a few drops of the serum onto your fingertips.
- Spread & Press – Dab the serum onto 5–6 areas of your face and neck, then gently smooth it outward for intense hydration.
- Boost Absorption – Using your fingertips, perform quick tapping movements from the forehead to the cheeks, then from the chin to the neck. This enhances absorption into the skin.
- Absorb – Allow the serum to fully sink in before applying additional products.
- Follow Up – Apply a moisturizer and sunscreen (if used in the morning) to lock in hydration. If using makeup, this serum creates a smooth base for foundation.
For best results, use morning and evening for a hydrated, plumper, and radiant complexion.